ANTIBODY DEVELOPMENT USING LAMP-BASED VECTORS FOR DNA IMMUNIZATION

  • DNA vaccination offers a unique alternative to develop antibodies against antigens which are poorly immunogenic or difficult to purify
  • Incorporating LAMP Technology into the immunization vector specifically targets the antigen into the MHC-II compartment
  • MHC-II antigen presentation activates the immune system through helper T-cells, possibly resulting in a robust antibody response
  • LAMP based vaccines have been designed to a wide variety of targets and have induced a strong immune response in animal systems
    • This includes infectious disease targets, cancer antigens, allergens and host proteins.
  • A LAMP immunization can be prepared in approximately 30 days and antisera recovered in approximately 75 days.