SCIENTIFIC BACKGROUND INFORMATION

1. Immune System Overview

This publication from the National Institutes of Health covers all the main topics including antibodies, T-cells, B-cells, IgG, IgE and natural versus acquired immunity – and of course, allergy.

2. DENDRITIC CELLS & DC THERAPY

One of the key types of cells active in the immune system is the dendritic cell. This document provides excellent background on how these cells process and present antigen to the immune system. It is the method used by Geron with their LAMP-based vaccine, GRNVAC1, targeting cancer cells with their proprietary target, telomerase.

 

3. AIRBORNE ALLERGENS

Basic information on allergies by the NIH, including a section on immunotherapy and allergy shots

 

4. HOW ALLERGIES WORK

A basic overview of the allergic mechanism

 

5. BEAUTY AND THE BEAST

A visually stunning piece on the Japanese red cedar tree, its historical and cultural significance and the widespread allergy problem it causes in Japan

 

6. THE JORDAN REPORT

This excellent study provides an in-depth analysis of the state of vaccine research

 

7. A Basic Overview of DNA vaccines

This is a one-paged document for the non-scientist with an overview of how DNA vaccines work

 

8. DNA Vaccines, ready for prime time?

This article on the current state of DNA vacinnes: Four DNA vaccine products have recently been approved, all in the area of veterinary medicine. These results suggest a productive future for this technology as more optimized constructs, better trial designs and improved platforms are being brought into the clinic.

 

9. DNA Vaccines for Targeting Bacterial Infections

This article describes the mechanism of action of DNA vaccines and their potential use for targeting bacterial infections. In addition, it provides an updated summary of the methods used to enhance immunogenicity from codon optimization and adjuvants to delivery techniques including electroporation and use of nanoparticles.

 

10. WAO White Book on Allergy

The White Book on Allergy is an important initiative by the World Allergy Organization calling on international and national health care policy makers to address early identification of symptoms, early diagnosis and appropriate strategies to manage and control allergies to avoid worsening of severe allergic disease to people at risk and to improve practice in this clinical field of medicine for the benefit of those suffering from the consequences of allergies. I congratulate the World Allergy Organization for initiating this timely and much needed document and wish them all success in its impact and implementation.

 

11. Background On The Application Of Lamp To Allergies

Allergy is potential to develop immunologically-controlled adverse reactions to normally harmless substances. Many factors commonly found in the environment can provoke an allergic response.

 

12. Lysosomal Associated Membrane Protein (LAMP) – Based Vaccines

LAMP Technology is an innovative vaccine platform that represents a leap forward in nucleic acid vaccine technology.

  • Directly induces active humoral immunity, and simultaneously
  • Directs a cell mediated response against a biological agent
  • For applications in allergy, infectious disease, and cancer