SCIENTIFIC BACKGROUND INFORMATION
One of the key types of cells active in the immune system is the dendritic cell. This document provides excellent background on how these cells process and present antigen to the immune system. It is the method used by Geron with their LAMP-based vaccine, GRNVAC1, targeting cancer cells with their proprietary target, telomerase.
This article on the current state of DNA vacinnes: Four DNA vaccine products have recently been approved, all in the area of veterinary medicine. These results suggest a productive future for this technology as more optimized constructs, better trial designs and improved platforms are being brought into the clinic.
This article describes the mechanism of action of DNA vaccines and their potential use for targeting bacterial infections. In addition, it provides an updated summary of the methods used to enhance immunogenicity from codon optimization and adjuvants to delivery techniques including electroporation and use of nanoparticles.
The White Book on Allergy is an important initiative by the World Allergy Organization calling on international and national health care policy makers to address early identification of symptoms, early diagnosis and appropriate strategies to manage and control allergies to avoid worsening of severe allergic disease to people at risk and to improve practice in this clinical field of medicine for the benefit of those suffering from the consequences of allergies. I congratulate the World Allergy Organization for initiating this timely and much needed document and wish them all success in its impact and implementation.
LAMP Technology is an innovative vaccine platform that represents a leap forward in nucleic acid vaccine technology.
- Directly induces active humoral immunity, and simultaneously
- Directs a cell mediated response against a biological agent
- For applications in allergy, infectious disease, and cancer